Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent progress in engineering the Pittsburgh intravenous membrane oxygenator

W J Federspiel1, T Hewitt, M S Hout

  • 1Department of Surgery, University of Pittsburgh, Pennsylvania 15219, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|September 1, 1996
PubMed
Summary

The University of Pittsburgh developed an improved intravenous membrane oxygenator (IMO) for enhanced gas exchange. Recent prototypes show promising oxygen delivery capabilities, nearing design goals for future clinical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Feasibility of a Composite Measure of Pulmonary Vascular Impedance and Application to Patients with Chronic RV Failure Post LVAD Implant.

Cardiovascular engineering and technology·2023
Same author

Associations of fluid amount, type, and balance and acute kidney injury in patients undergoing major surgery.

Anaesthesia and intensive care·2018
Same author

Acidic sweep gas with carbonic anhydrase coated hollow fiber membranes synergistically accelerates CO2 removal from blood.

Acta biomaterialia·2015
Same author

Kinetics of CO2 exchange with carbonic anhydrase immobilized on fiber membranes in artificial lungs.

Journal of materials science. Materials in medicine·2015
Same author

Carbonic anhydrase immobilized on hollow fiber membranes using glutaraldehyde activated chitosan for artificial lung applications.

Journal of materials science. Materials in medicine·2013
Same author

The Subcutaneous Use of Creasote and Guaiacol in Pulmonary Phthisis.

British medical journal·2010

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Respiratory Support

Background:

  • The intravenous membrane oxygenator (IMO) is being engineered for enhanced gas exchange.
  • The device aims to support up to 50% of basal oxygen consumption and CO2 elimination.
  • It is designed for insertion into the inferior and superior vena cavae via peripheral venous access.

Purpose of the Study:

  • To further develop and characterize the University of Pittsburgh's intravenous membrane oxygenator (IMO).
  • To assess the feasibility of the IMO device for partial cardiopulmonary support.
  • To optimize the engineering design for improved gas exchange efficiency and operational parameters.

Main Methods:

  • Fabrication and extensive bench testing of over 15 IMO prototypes.

Related Experiment Videos

  • Characterization of oxygen (O2) gas exchange capacity and balloon pulsation dynamics.
  • Analysis of sweep gas pathway pneumatics and engineering redesign of gas flow paths.

    • Main Results:

    • Engineering changes led to increased maximum balloon pulsation rate from 70 bpm to 160 bpm.
    • Reduced vacuum pressure is now required for adequate sweep gas flow.
    • Prototypes demonstrated O2 exchange capacity up to 90 ml/min/m² in water, achieving 70% of the scaled-up blood-based design goal.

    Conclusions:

    • Significant engineering improvements have been made to the IMO device.
    • The enhanced IMO prototypes show improved performance in gas exchange and operational efficiency.
    • The device shows potential for partial cardiopulmonary support, nearing established design objectives.