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Continuous hyperthermic peritoneal perfusion for peritoneal carcinomatosis

Y C Chung1, M T Huang, C N Chang

  • 1Department of Surgery, Provincial Hsin-Chu Hospital, Hsin-Chu City.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|February 1, 1996
PubMed
Summary

Continuous hyperthermic peritoneal perfusion (CHPP) is a potentially safe treatment for peritoneal carcinomatosis. While some patients showed improvement, long-term benefits require further study in digestive tract cancer.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Gastroenterology

Background:

  • Peritoneal carcinomatosis is a common complication of digestive tract cancers.
  • Standard treatments have limitations in managing widespread peritoneal disease.
  • Cytoreductive surgery followed by chemotherapy is a treatment option.

Purpose of the Study:

  • To evaluate the safety and efficacy of continuous hyperthermic peritoneal perfusion (CHPP) in patients with peritoneal carcinomatosis.
  • To assess the impact of CHPP on ascites and patient survival.
  • To identify potential complications associated with CHPP.

Main Methods:

  • CHPP was administered to 10 patients with digestive tract cancer and peritoneal carcinomatosis.
  • The perfusion involved warm saline with mitomycin-C and 5-flurouracil at 42-43°C for 60 minutes.

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  • Patients had undergone resection of primary and/or metastatic lesions prior to CHPP.

    • Main Results:

    • Three patients experienced disappearance of preoperative ascites.
    • Five patients survived for over 1 year post-CHPP.
    • Transient liver function, white blood cell count, and albumin level changes were observed, but no significant immediate postoperative complications.

    Conclusions:

    • CHPP appears to be a safe treatment modality for peritoneal carcinomatosis.
    • Further investigation is needed to establish the long-term benefits of CHPP.
    • CHPP may offer a survival advantage for select patients with advanced gastrointestinal malignancies.