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[Endoscopic contamination with Mycobacterium tuberculosis]

G Izbicki1, W Mosimann, C T Bolliger

  • 1Departement für Innere Medizin, Universitätskliniken, Kantonsspital Basel.

Schweizerische Medizinische Wochenschrift
|February 1, 1997
PubMed
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A chronic cough case initially diagnosed as tuberculosis due to positive cultures was later revised. Molecular typing revealed contamination, highlighting the importance of accurate diagnostic methods for respiratory infections.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Microbiology

Background:

  • Chronic cough is a common respiratory symptom requiring thorough investigation.
  • Distinguishing between chronic bronchitis and endobronchial tuberculosis can be challenging based on initial clinical and radiological findings.

Observation:

  • A 60-year-old woman presented with chronic cough, unresponsive to prior treatments.
  • Bronchial aspirate cultures were positive for Mycobacterium tuberculosis, leading to a diagnosis of endobronchial tuberculosis.
  • The patient exhibited a hypersensitivity reaction to isoniazid, a key component of the tuberculosis treatment regimen.

Findings:

  • Initial diagnosis of endobronchial tuberculosis was based on positive cultures and clinical presentation.
  • Subsequent molecular typing of the samples identified contamination, invalidating the initial tuberculosis diagnosis.

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  • The patient's symptoms were likely due to chronic bronchitis, not tuberculosis.

    • Implications:

    • This case underscores the critical need for stringent laboratory protocols to prevent sample contamination.
    • Accurate microbial identification is essential for correct diagnosis and effective treatment of respiratory conditions.
    • Misdiagnosis can lead to unnecessary treatment, adverse drug reactions, and delayed management of the actual underlying condition.