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Updated: Sep 19, 2026
An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
[Prevention of superficial bladder cancer with mitomycin C or interferon: final results of a prospective study]
A Ojea Calvo1, F Domínguez Freire, M Vérez Vivero
1Servicio de Urología, Hospital Xeral de Vigo, Pontevedra, España.
Objectives:
Herein we present the final results of a prospective randomized study comparing two prophylactic treatment modalities for superficial bladder tumors: chemotherapy with mitomycin C and immunotherapy with interferon.
Methods:
The study comprised 65 patients. Mitomycin C was utilized in 34 and interferon in 31 patients.
Results:
The mitomycin C-treated patients had 41% recurrence, 1.7 recurrence/100 patients-month, 17 months mean time to recurrence and 8.8% tumor progression. The patients receiving interferon had 45% recurrence, 2.4 recurrence/100 patients-month, 12 months mean time to recurrence and 22.2% tumor progression rate. No significant differences were observed between the two groups of patients. Treatment was well-tolerated by both groups and the cost:efficacy ratio was higher for the interferon-treated patients.
Conclusions:
Immunoprophylaxis with interferon is as effective, but costs more than chemoprophylaxis with mitomycin C. Both agents have a moderate effect relative to control of recurrence, time to recurrence and tumor progression.
