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Intercircuit control of motor pattern modulation by presynaptic inhibition

M Bartos1, M P Nusbaum

  • 1Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|April 1, 1997
PubMed
Summary

Neural networks control their own modulation. In crabs, rhythmic inhibition of a modulatory neuron weakens one network while allowing it to strengthen another, demonstrating rhythmic control of distinct circuits.

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Rhythmically active neural networks can regulate their own modulatory input.
  • Presynaptic inhibition is a key mechanism for controlling synaptic transmission.

Purpose of the Study:

  • To investigate how rhythmic presynaptic inhibition influences the activity of distinct, but related, neural circuits.
  • To elucidate the role of gastric mill rhythm-timed presynaptic inhibition on the pyloric rhythm in the crab stomatogastric ganglion (STG).

Main Methods:

  • Electrophysiological recordings in the crab STG.
  • Analysis of synaptic interactions between neural networks.
  • Perturbation of neural circuit activity through stimulation and inhibition.

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Main Results:

  • Gastric mill rhythm-timed presynaptic inhibition of modulatory commissural neuron 1 (MCN1) rhythmically interrupts MCN1-mediated excitation of the pyloric rhythm.
  • During gastric mill protraction, presynaptic inhibition weakens the pyloric rhythm.
  • During gastric mill retraction, absence of presynaptic inhibition allows MCN1 to elicit a faster, stronger pyloric rhythm.

Conclusions:

  • Presynaptic inhibition enables neural circuits to regulate their own modulatory input.
  • Presynaptic inhibition is utilized to rhythmically control the activity of behaviorally related neural circuits.
  • This study reveals a novel mechanism of inter-network communication and control through rhythmic modulation.