Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dissociation of mnemonic coding and other functional neuronal processing in the monkey prefrontal cortex

S Carlson1, P Rämä, H Tanila

  • 1Department of Physiology, University of Helsinki, Finland.

Journal of Neurophysiology
|February 1, 1997
PubMed
Summary

Prefrontal cortex neurons in monkeys were studied during a spatial delayed alternation (DA) task. Most neurons active during the memory task

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age and sex dependent hippocampal neuronal hyperactivity in Alzheimer model mice.

Experimental neurology·2026
Same author

Novel object recognition task for mice: Is it a test for memory, object neophobia or innate preference?

Behavioural brain research·2025
Same author

Intracerebroventricular phospho-tau immunotherapy alleviates cortical phospho-tau burden and motor phenotype in a neuron-specific P301S tauopathy mouse.

Experimental neurology·2025
Same author

Prospective Multicenter Observational Study of Patients in Shock Treated with Vasopressin: VASOPRES Registry Study Protocol.

Revista espanola de anestesiologia y reanimacion·2025
Same author

Potential <i>in-vitro</i> antioxidant and anti-inflammatory activity of <i>Martynia annua</i> extract mediated Phytosynthesis of MnO<sub>2</sub> nanoparticles.

Heliyon·2024
Same author

Photo Quiz: Therapeutic Contact Lens-Associated Fungal Keratitis.

Journal of clinical microbiology·2023

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Primate Neurophysiology

Background:

  • The prefrontal cortex is crucial for cognitive functions, including working memory.
  • Understanding neuronal activity during memory tasks is key to elucidating mnemonic processing.
  • Previous research suggests prefrontal cortex involvement in spatial working memory.

Purpose of the Study:

  • To investigate the relationship between mnemonic neuronal processing and other functional neuronal responses in the prefrontal cortex.
  • To characterize single-neuron activity during a spatial delayed alternation (DA) task in monkeys.
  • To differentiate task-related neuronal activity from sensory-evoked responses.

Main Methods:

  • Single-neuron activity was recorded in the prefrontal cortex of three monkeys.

Related Experiment Videos

  • Recordings were conducted during a spatial delayed alternation (DA) task and sensory stimulation (visual, auditory, somatosensory).
  • Neuronal firing patterns were analyzed in relation to task performance and stimulus presentation.

    • Main Results:

    • 32% of prefrontal neurons fired in relation to the DA task; 39% responded to sensory stimuli or movements.
    • Most task-related neurons (73%) fired during the delay period, with 79% of these being spatially selective.
    • Delay-related neurons were largely unresponsive to extrinsic sensory stimuli, indicating specialized processing.

    Conclusions:

    • The dorsolateral prefrontal cortex plays a significant role in spatial working memory.
    • A majority of delay-related prefrontal neurons engaged in the DA task are specialized for processing task-specific information.
    • These findings highlight the selective nature of prefrontal neuronal responses during mnemonic tasks.