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Striatal dopamine D1 receptors in narcolepsy: a PET study with [11C]NNC 756
J O Rinne1, C Hublin, M Partinen
1Department of Neurology, University of Turku, Finland.
Journal of Sleep Research
|December 1, 1996
Abstract:
We investigated dopamine D1 receptors in the putamen and caudate nucleus with positron emission tomography in six patients with narcolepsy and five healthy controls using [11C]NNC 756 as ligand. The caudate-to-cerebellum and putamen-to-cerebellum ratios of [11C]NNC 756 were within normal limits in patients with narcolepsy. No evidence of increased D1 receptor binding in narcolepsy was found.