Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gonadotropin-releasing hormone neurons: their structure and function

G E Hoffman1, K A Berghorn

  • 1Department of Anatomy and Neurobiology, University of Maryland, Baltimore 21201, USA.

Seminars in Reproductive Endocrinology
|February 1, 1997
PubMed
Summary

Gonadotropin-releasing hormone (GnRH) neurons control reproduction by releasing GnRH. Their unique migratory development from the olfactory epithelium influences reproductive function and GnRH neuron distribution.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ORE identifies extreme expression effects enriched for rare variants.

Bioinformatics (Oxford, England)·2019
Same author

Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions.

Nature communications·2017
Same author

Development and Characterization of Novel Rat Anti-mERβ Sera.

Endocrinology·2016
Same author

cFos Activity Identifies Recruitment of Luteinizing Hormone-Releasing Hormone Neurons During the Ascending Phase of the Proestrous Luteinizing Hormone Surge.

Journal of neuroendocrinology·2011
Same author

Kisspeptin and the preovulatory gonadotrophin-releasing hormone/luteinising hormone surge in the ewe: basic aspects and potential applications in the control of ovulation.

Journal of neuroendocrinology·2010
Same author

c-Fos Expression in Rat Brain and Brainstem Nuclei in Response to Treatments That Alter Food Intake and Gastric Motility.

Molecular and cellular neurosciences·2009

Area of Science:

  • Neuroendocrinology
  • Reproductive Biology
  • Developmental Neuroscience

Background:

  • Gonadotropin-releasing hormone (GnRH) neurons are critical for mammalian reproduction.
  • Pulsatile GnRH release is essential for regulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion.
  • The unique embryonic origin and migratory path of GnRH neurons from the olfactory epithelium influence their distribution and function.

Purpose of the Study:

  • To elucidate the developmental origins and anatomical organization of GnRH neurons.
  • To understand the regulatory mechanisms controlling GnRH neuron activity.
  • To differentiate between permissive and directive influences on GnRH release.

Main Methods:

  • Review of existing literature on GnRH neuron development and function.

Related Experiment Videos

  • Analysis of anatomical studies detailing GnRH neuron distribution.
  • Synthesis of recent findings on the neurochemical control of GnRH neurons.

    • Main Results:

    • GnRH neurons originate in the olfactory epithelium and migrate to the hypothalamus.
    • This migratory process explains the atypical distribution of GnRH neurons and links olfactory and reproductive systems.
    • Distinguishing between permissive and directive neural inputs to GnRH neurons is crucial for understanding reproductive regulation.

    Conclusions:

    • The unique developmental trajectory of GnRH neurons profoundly impacts reproductive neurobiology.
    • Understanding the complex neural network controlling GnRH neurons is key to deciphering reproductive cycles.
    • Further research into the permissive and directive signals will advance reproductive medicine.