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The perimenopause and affective disorders

P J Schmidt1, C A Roca, M Bloch

  • 1Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, Maryland 20892-1276, USA.

Seminars in Reproductive Endocrinology
|February 1, 1997
PubMed
Summary
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Many postmenopausal women do not experience depression during perimenopause. However, research indicates a significant number do experience clinically significant depression, requiring evaluation and management strategies.

Area of Science:

  • Reproductive medicine
  • Women's health
  • Psychiatry

Background:

  • Perimenopause is a transitional phase in women's reproductive health.
  • Depression during perimenopause is a recognized clinical concern.
  • Epidemiologic data present conflicting views on the prevalence of depression during this phase.

Purpose of the Study:

  • To review existing epidemiologic studies on perimenopause-related depression.
  • To discuss the characteristics of depression during this life stage.
  • To identify contributing factors and provide management recommendations.

Main Methods:

  • Review of epidemiologic studies and clinic-based surveys.
  • Analysis of case examples.
  • Identification of midlife factors impacting mood.

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Main Results:

  • While most postmenopausal women do not experience depression, a substantial subset of perimenopausal women do.
  • Specific characteristics of perimenopause-related depression are identified.
  • Several midlife factors are associated with mood dysregulation.

Conclusions:

  • Perimenopause-related depression is a clinically significant condition affecting a notable number of women.
  • Understanding contributing factors is crucial for effective management.
  • Evidence-based strategies for evaluation and treatment are essential.