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Mild hyperhomocysteinemia and hemostatic factors in patients with arterial vascular diseases

G Freyburger1, S Labrouche, G Sassoust

  • 1Laboratoire d'Hématologie, Hôpital Pellegrin, Bordeaux, France.

Thrombosis and Haemostasis
|March 1, 1997
PubMed

Insights

Mild hyperhomocysteinemia is linked to premature arterial disease. Elevated homocysteine levels, particularly after methionine loading, correlate with more pronounced alterations in blood clotting and fibrinolytic parameters.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Metabolic Disorders

Background:

  • Mild hyperhomocysteinemia, from genetic or environmental factors, is a known risk factor for premature arterial disease.
  • Arterial diseases include peripheral arterial occlusion, thrombotic stroke, and myocardial infarction.
  • Hyperhomocysteinemia can be identified by elevated fasting homocysteine or increased levels after methionine loading.

Purpose of the Study:

  • To investigate hemostatic parameters in patients with premature arterial disease.
  • To determine if hyperhomocysteinemia influences specific hemostatic alterations in these patients.

Main Methods:

  • Studied 88 patients with premature arterial disease (mean age 43 ± 11 years).
  • Assessed hemostatic parameters, comparing them between hyperhomocysteinemic and non-hyperhomocysteinemic patients.
  • Analyzed alterations based on fasting homocysteine and post-methionine load homocysteine levels.

Main Results:

  • Confirmed known hemostatic alterations in vascular patients compared to controls.
  • Patients with elevated fasting homocysteine showed greater alterations in factors VIIIc, von Willebrand, and thrombin-antithrombin complexes.
  • Patients with elevated post-methionine load homocysteine exhibited more pronounced changes in fibrinolytic parameters.

Conclusions:

  • Hyperhomocysteinemia is associated with distinct hemostatic and fibrinolytic alterations in patients with premature arterial disease.
  • The pattern of hemostatic changes differs depending on whether fasting or post-methionine load homocysteine levels are elevated.
  • These findings highlight the importance of homocysteine levels in understanding the pathophysiology of arterial disease.

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