Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intracavernous pharmacotherapy

M C Truss1, A J Becker, D Schultheiss

  • 1Department of Urology, Medizinische Hochschule Hannover, Germany.

World Journal of Urology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optical analysis of glutamate spread in the neuropil.

Cerebral cortex (New York, N.Y. : 1991)·2022
Same author

Volumetry of Mesiotemporal Structures Reflects Serostatus in Patients with Limbic Encephalitis.

AJNR. American journal of neuroradiology·2019
Same author

Review: Animal models of acquired epilepsy: insights into mechanisms of human epileptogenesis.

Neuropathology and applied neurobiology·2017
Same author

Micro-endoscopy of the human vas deferens: a feasibility study of a novel device in several ex vivo models.

Andrology·2016
Same author

Seizure control and cognitive improvement via immunotherapy in late onset epilepsy patients with paraneoplastic versus GAD65 autoantibody-associated limbic encephalitis.

Epilepsy & behavior : E&B·2016
Same author

Metabolic syndrome and the seminal cytokine network in morbidly obese males.

Andrology·2016
Same journal

Safety and efficacy of different surgical approaches in single-port robot-assisted radical prostatectomy based on propensity score matching analysis.

World journal of urology·2026
Same journal

Intrarenal pressure and clinical outcomes during suction-assisted versus conventional percutaneous nephrolithotomy: a systematic review and meta-analysis.

World journal of urology·2026
Same journal

AI-driven model for early failure prediction after HIFU integrating immediate post-ablation ultrasound and clinical data.

World journal of urology·2026
Same journal

Comment on "Nurse-led postoperative telemonitoring program following outpatient urethroplasty: a pilot study".

World journal of urology·2026
Same journal

What should the urologist know on the management of kidney cancer in patients with Von Hippel-Lindau syndrome? Recommendations of the European Association of Urology (EAU) Young Academic Urologists (YAU) Renal Cancer Working Group.

World journal of urology·2026
Same journal

Modified HoLEP technique: does it preserve ejaculation?

World journal of urology·2026
See all related articles

Intracavernous vasoactive substance injections have revolutionized erectile dysfunction (ED) treatment by improving penile hemodynamics and enabling local drug delivery. This approach offers effective erection induction with minimal systemic side effects for many patients.

Area of Science:

  • Urology
  • Pharmacology
  • Physiology

Background:

  • Intracavernous injections of vasoactive substances have significantly advanced the understanding and treatment of erectile dysfunction (ED).
  • Pioneering work by Virag and Brindley established the efficacy of papaverine and alpha-receptor blockers, respectively, in inducing erections.
  • These discoveries led to the development of intracavernous pharmacotherapy as a primary treatment for ED.

Purpose of the Study:

  • To review the impact of intracavernous vasoactive substance application on penile hemodynamics and ED treatment.
  • To highlight the physiological mechanisms underlying intracavernous injections for inducing erections.
  • To discuss established and emerging pharmacologic agents for ED management.

Main Methods:

  • Review of historical and current literature on intracavernous pharmacotherapy for ED.

Related Experiment Videos

  • Analysis of the hemodynamic changes induced by vasoactive substances.
  • Discussion of commonly used and experimental drugs for intracavernous administration.

    • Main Results:

    • Intracavernous injections induce erections by promoting smooth muscle relaxation, increasing arterial inflow, and restricting venous outflow.
    • Local administration achieves high drug concentrations with reduced systemic side effects.
    • Established agents include papaverine, phentolamine, and prostaglandin E1 (alprostadil).

    Conclusions:

    • Intracavernous vasoactive therapy is a cornerstone in ED management, offering a localized and effective treatment option.
    • Ongoing research explores novel compounds and administration routes for future ED therapies.
    • Understanding penile hemodynamics is crucial for optimizing intracavernous injection treatments.