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The evolution of ribonucleotide reduction

P Reichard1

  • 1Medical Nobel Institute for Biochemistry, Karolinska Institutet, Stockholm, Sweden. peter.reichard@mbb.ki.se

Trends in Biochemical Sciences
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

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Ribonucleotide reduction, crucial for DNA synthesis, involves free radical chemistry. Three distinct classes of ribonucleotide reductases exist, each with unique radical generation mechanisms, raising questions about their evolutionary origins.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Ribonucleotide reduction is vital for converting RNA to DNA precursors.
  • This essential reaction relies on complex free radical chemistry.
  • Three distinct classes of ribonucleotide reductases (RNRs) are currently known.

Purpose of the Study:

  • To explore the evolutionary origins of the three different classes of ribonucleotide reductases.
  • To investigate whether these RNR classes evolved from a common ancestor or represent independent evolutionary events.
  • To understand the role of atmospheric oxygen in the divergence of RNRs.

Main Methods:

  • Comparative analysis of the three known classes of ribonucleotide reductases.
  • Investigation of the distinct mechanisms employed by each RNR class for stable free radical amino acid generation.

Related Experiment Videos

  • Bioinformatic and phylogenetic analyses to infer evolutionary relationships.

    • Main Results:

    • All three RNR classes utilize a stable free radical amino acid.
    • Each class employs a unique mechanism for generating this essential free radical.
    • The study highlights significant differences in their radical generation strategies.

    Conclusions:

    • The distinct evolutionary pathways of the three RNR classes remain an open question.
    • Further research is needed to determine if they share a common ancestor or evolved independently.
    • The emergence of atmospheric oxygen may have influenced their divergent evolution.