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Benzophenone photoprobes for phosphoinositides, peptides and drugs
G D Prestwich1, G Dormán, J T Elliott
1Department of Chemistry, University at Stony Brook, NY, USA. gprestwich@deans.pharm.utah.edu
Photochemistry and Photobiology
|February 1, 1997
Abstract:
Benzophenones (BP) and related aryl ketone photophores have become established as the photoactivatable group of choice for high-efficiency covalent modification of hydrophobic regions of binding proteins, including enzymes and receptors that recognize peptide hormones, (oligo) nucleotides and nucleosides, phosphoinositides, inositol polyphosphates and a wide variety of therapeutic molecules. This review presents the advantages of BP as photoaffinity labels and provides specific examples from the last 3 years of applications of BP-containing ligands used in biochemistry.