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Effects of aspirin on platelet aggregation in smokers and nonsmokers
C Chant1, S C Fagan, S K Aurora
1Department of Pharmacy Services, Henry Ford Hospital, Detroit, MI, USA.
Objective:
To assess the relative antiaggregatory ability of aspirin on platelets of smoking and nonsmoking healthy volunteers.
Design:
Prospective, randomized, crossover study.
Setting:
Tertiary-care teaching institution.
Subjects:
Eighteen healthy smoking and nonsmoking male volunteers.
Interventions:
Each subject received aspirin 325 mg or ticlopidine 250 mg bid as an active control for 7 days in a crossover manner separated by a 1-month washout period. Whole blood platelet aggregation was measured on four occasions, twice at baseline and once after each drug treatment.
Outcome Measurement:
Whole blood ex vivo platelet aggregation in terms of impedance (omega) and adenosine triphosphate (ATP) release (nmol), as assessed using Lumi-aggregometry.
Results:
Aspirin was associated with significantly less ATP release in both smokers (p = 0.01) and nonsmokers (p = 0.003). No significant differences in platelet aggregation were found between smokers and nonsmokers at baseline or with any treatment phases. Sixty-seven percent and 17% of volunteers receiving ticlopidine and aspirin, respectively, reported adverse effects.
Conclusions:
Twice-daily administration of aspirin for 7 days to healthy volunteers was well tolerated and also reduced platelet aggregation significantly regardless of smoking status.