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Magnesium and gastric acid secretion

I Puscas, F Nadaban, L Voicu

    Acta Hepato-Gastroenterologica
    |August 1, 1977
    PubMed
    Summary

    Magnesium supplements do not alter gastric acid secretion in duodenal ulcer patients. However, magnesium counteracts calcium

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    Area of Science:

    • Gastroenterology
    • Pharmacology

    Background:

    • Gastric acid secretion is crucial in duodenal ulcer pathogenesis.
    • The roles of magnesium and calcium in modulating gastric acid require further elucidation.

    Purpose of the Study:

    • To investigate the effects of various magnesium compounds on gastric acid secretion in duodenal ulcer patients.
    • To explore the interactions between calcium and magnesium, and between acetazolamide and magnesium on gastric acid secretion.

    Main Methods:

    • 805 patients with duodenal ulcers were studied.
    • Administration of magnesium oxide, peroxide, silicate, and sulphate was evaluated.
    • Calcium-magnesium antagonism and acetazolamide-magnesium synergia were investigated.

    Main Results:

    • Oral or parenteral magnesium did not significantly alter basal or histamine-stimulated gastric acid secretion.
    • Calcium gluconate infusion significantly increased gastric acid secretion.
    • Magnesium sulphate antagonized the acid-stimulating effect of calcium.
    • Magnesium oxide enhanced acetazolamide's inhibitory effect on gastric acid secretion.

    Conclusions:

    • Magnesium does not directly modify gastric acid secretion but plays a crucial role in antagonizing calcium's effects.
    • Magnesium enhances the efficacy of acetazolamide in inhibiting gastric acid secretion.
    • Magnesium is essential in antacid formulations to counteract potential adverse effects of calcium.

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