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Related Experiment Videos

Chronic relapsing experimental allergic encephalomyelitis. Studies in vascular permeability changes

K Kristensson, H M Wiśniewski

    Acta Neuropathologica
    |August 31, 1977
    PubMed
    Summary

    In chronic relapsing experimental autoimmune encephalomyelitis (EAE), the blood-brain barrier becomes permeable to protein tracers in demyelinating plaques. This finding suggests similarities between EAE lesions and those seen in multiple sclerosis.

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    Area of Science:

    • Neuroscience
    • Immunology
    • Pathology

    Background:

    • Experimental autoimmune encephalomyelitis (EAE) is an animal model for demyelinating diseases.
    • Chronic relapsing EAE in guinea pigs exhibits clinical and pathological features relevant to multiple sclerosis.

    Purpose of the Study:

    • To investigate vascular permeability in the nervous system during chronic relapsing EAE.
    • To compare the blood-brain barrier integrity in EAE lesions with multiple sclerosis.

    Main Methods:

    • Studied vascular permeability using protein tracers (Evans blue-albumin and horseradish peroxidase).
    • Utilized chronic relapsing EAE model in strain 13 and Hartley guinea pigs.
    • Examined spinal cord lesions from animals with induced EAE.

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    Main Results:

    • Increased vascular permeability to protein tracers was observed in demyelinating plaques.
    • Both recent and old demyelinating plaques showed enhanced permeability.
    • The blood-brain barrier was found to be disturbed in these lesions.

    Conclusions:

    • Demyelinating plaques in chronic relapsing EAE demonstrate a compromised blood-brain barrier.
    • The observed vascular changes in EAE lesions resemble those found in multiple sclerosis lesions.
    • This study highlights the utility of EAE as a model for understanding blood-brain barrier dysfunction in multiple sclerosis.