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Related Experiment Videos

Icodextrin's effects on peritoneal transport

R T Krediet1, M M Ho-dac-Pannekeet, A L Imholz

  • 1Renal Unit, Academic Medical Center, University of Amsterdam, The Netherlands.

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|January 1, 1997
PubMed
Summary
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Icodextrin enhances peritoneal fluid removal and beta 2-microglobulin clearance in continuous ambulatory peritoneal dialysis (CAPD) patients, particularly during long dwells or with ultrafiltration failure. It improves convective transport without altering peritoneal membrane permeability.

Area of Science:

  • Nephrology
  • Renal Physiology
  • Peritoneal Dialysis

Background:

  • Peritoneal fluid and solute transport are crucial in peritoneal dialysis.
  • Understanding transport principles aids in optimizing dialysis strategies.

Purpose of the Study:

  • To review peritoneal fluid transport principles.
  • To analyze icodextrin's effects on fluid and solute transport in CAPD.

Main Methods:

  • Literature review and analysis of patient data.
  • Focus on icodextrin's impact in continuous ambulatory peritoneal dialysis (CAPD).

Main Results:

  • Icodextrin did not alter low molecular weight solute transfer or albumin clearance.
  • Beta 2-microglobulin clearance increased due to convective transport with icodextrin.

Related Experiment Videos

  • Icodextrin improved ultrafiltration during long dwells, peritonitis, and in patients with high transport rates.

    • Conclusions:

    • Icodextrin enhances convective flow via the small-pore system without changing peritoneal membrane permeability.
    • It increases peritoneal clearance of beta 2-microglobulin compared to glucose solutions.
    • Icodextrin is beneficial for long dwells and patients with ultrafiltration issues due to large peritoneal surface area.