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Repression of the 5-lipoxygenase gene by c-myb overexpression in differentiated HL-60 cells
A Ponton1, J P Thirion, P Sirois
1Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, P.Q., Canada.
Prostaglandins
|January 1, 1997
Abstract:
This paper reports on the involvement of c-MYB in the regulation of 5-lipoxygenase gene expression during differentiation of human HL-60 cells. We demonstrate that c-MYB binds the 5-lipoxygenase promoter in undifferentiated cells but not in DMSO-differentiated cells. Also, we show that overexpression of c-myb cDNA in differentiated HL-60 cells represses the 5-lipoxygenase gene expression.