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Controlled pilot study of rapid amphotericin B infusions
H Dele Davies1, S M King, J Doyle
1Department of Paediatrics, Hospital for Sick Children, Toronto, Canada.
Archives of Disease in Childhood
|February 1, 1997
Summary
This study compared one-hour versus four-hour amphotericin B infusions in children. Shorter infusions caused more chills, while longer infusions led to increased hypotension, indicating differing toxicity profiles.
Area of Science:
- Pediatric Pharmacology
- Infectious Disease Treatment
- Clinical Toxicology
Background:
- Amphotericin B is a critical antifungal agent.
- Infusion protocols for amphotericin B vary.
- Optimizing infusion strategies is crucial for pediatric patient safety.
Purpose of the Study:
- To compare the toxicity of a one-hour versus a four-hour infusion of amphotericin B in pediatric patients.
- To identify specific adverse events associated with different infusion rates.
- To inform clinical practice regarding safe amphotericin B administration in children.
Main Methods:
- A pilot study design was employed.
- Pediatric patients received amphotericin B via either a one-hour or a four-hour infusion.
- Adverse events, including chills and hypotension, were monitored and compared between groups.
Main Results:
- Patients receiving the one-hour infusion experienced more severe chills on the first day.
- Patients receiving the four-hour infusion exhibited more instances of hypotension throughout the study duration.
- These findings suggest distinct toxicity patterns based on infusion length.
Conclusions:
- Infusion duration significantly impacts amphotericin B toxicity in children.
- One-hour infusions are associated with acute febrile reactions (chills).
- Four-hour infusions are linked to hemodynamic instability (hypotension), necessitating careful monitoring.