Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in nosocomial pneumonia in ventilated patients by selective oropharyngeal decontamination (SOD)

M Abele-Horn1, A Dauber, A Bauernfeind

  • 1Max von Pettenkofer-Institut, Ludwig-Maximilians-Universität, München, Germany.

Intensive Care Medicine
|February 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consensus and controversies about diagnosing GH deficiency: a Delphi survey by the GH research society.

Pituitary·2025
Same author

[CF Lung Disease - a German S3 Guideline: Module 2: Diagnostics and Treatment in Chronic Infection with Pseudomonas aeruginosa].

Pneumologie (Stuttgart, Germany)·2018
Same author

[Epidemiology, Diagnosis and Treatment of Adult Patients with Nosocomial Pneumonia - Update 2017 - S3 Guideline of the German Society for Anaesthesiology and Intensive Care Medicine, the German Society for Infectious Diseases, the German Society for Hygiene and Microbiology, the German Respiratory Society and the Paul-Ehrlich-Society for Chemotherapy, the German Radiological Society and the Society for Virology].

Pneumologie (Stuttgart, Germany)·2018
Same author

Accelerated Skeletal Maturation in Disorders of Retinoic Acid Metabolism: A Case Report and Focused Review of the Literature.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2016
Same author

Hygiene monitoring in a hospital immunohaematological laboratory.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2015
Same author

[Surveillance of antibiotic consumption : clarification of the "definition of data on the nature and extent of antibiotic consumption in hospitals according to § 23 paragraph 4 sentence 2 of the IfSG"].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2013
Same journal

Publisher Correction: Current knowledge and challenges of sepsis-associated encephalopathy.

Intensive care medicine·2026
Same journal

Prehospital airway and ventilatory management: a collaborative and narrative review.

Intensive care medicine·2026
Same journal

Rapid coma with bilateral basal ganglia involvement.

Intensive care medicine·2026
Same journal

From size to function: moving beyond body mass index to frailty and central adiposity phenotypes.

Intensive care medicine·2026
Same journal

Effects of a clinical metagenomics intervention on clinical outcomes, healthcare costs, and health-related quality of life in patients with sepsis or septic shock: results of the randomized-controlled DigiSep trial.

Intensive care medicine·2026
Same journal

Hypercalcemia in intensive care unit: pathophysiological mechanisms and clinical implications.

Intensive care medicine·2026
See all related articles

Selective oropharyngeal decontamination (SOD) significantly reduced respiratory tract colonization and pneumonia in intensive care unit patients. While not impacting length of stay or mortality, SOD lowered antibiotic costs without observed resistance.

Area of Science:

  • Critical care medicine
  • Infectious diseases
  • Pharmacology

Background:

  • Intensive care unit (ICU) patients on mechanical ventilation are at high risk for respiratory tract colonization and infection.
  • Selective oropharyngeal decontamination (SOD) is a strategy to prevent infections in this vulnerable population.

Purpose of the Study:

  • To evaluate the effectiveness of SOD in reducing respiratory tract colonization and infection rates.
  • To assess the impact of SOD on ICU length of stay, duration of ventilation, and mortality.
  • To perform a financial assessment of SOD implementation.

Main Methods:

  • A randomized, prospective, controlled study was conducted in an anesthesiology ICU.
  • 88 patients requiring mechanical ventilation were enrolled, with 58 receiving SOD (amphotericin B, colistin sulfate, tobramycin) and 30 serving as controls.

Related Experiment Videos

  • Microbiological samples were collected from the oropharynx and infected sites throughout the study period.

    • Main Results:

    • SOD significantly reduced oropharyngeal colonization and the rate of pneumonia (22% in SOD group vs. 77% in controls).
    • Staphylococcus aureus was identified as the primary pathogen.
    • No significant differences were observed in ICU length of stay, duration of ventilation, or mortality.
    • Total antibiotic costs were reduced, and no development of resistance was noted.

    Conclusions:

    • Selective oropharyngeal decontamination is effective in decreasing respiratory tract colonization and pneumonia in mechanically ventilated ICU patients.
    • SOD led to a significant reduction in antibiotic charges without increasing resistance.
    • Further observation is needed to understand the clinical relevance of Staphylococcus aureus selection by SOD.