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Related Experiment Videos

Argyrophilia in the developing human myenteric plexus

V V Smith1, P J Milla

  • 1Histopathology Department, Great Ormond Street Hospital for Children NHS Trust, London, UK.

British Journal of Biomedical Science
|December 1, 1996
PubMed
Summary
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The development of silver-staining patterns in enteric neurons varies significantly in infants. Age is crucial for interpreting silver-stained colonic tissue in infants with intestinal pseudo-obstruction.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Gastroenterology

Background:

  • Silver staining is used to visualize enteric neurons.
  • Absence of argyrophilic neurons is linked to infant intestinal obstruction.
  • Limited data exist on normal enteric neuron development and argyrophilia.

Purpose of the Study:

  • To investigate the origin and development of argyrophilia in enteric neurons.
  • To establish normal neuronal appearances in the colon.
  • To assess the impact of age on neuronal silver staining.

Main Methods:

  • Silver staining of colon specimens from 48 infants and children (pre-term to 14 years).
  • Analysis of neuronal size, morphology, and staining intensity (strong, faint, absent).

Related Experiment Videos

  • Categorization based on argyrophilia: strong, absent, or weak.

    • Main Results:

    • Significant inter-sample variation in neuronal staining intensity observed.
    • No argyrophilia seen in preterm infants; present in infants over one year.
    • Weak argyrophilia observed across a broad age range.
    • Argyrophobic neurons outnumbered argyrophilic ones (median 9:1 ratio).

    Conclusions:

    • Colonic myenteric neuron appearance and argyrophilia show considerable variability in the first year of life.
    • Findings suggest ongoing post-natal development of the enteric nervous system, similar to the brain.
    • Age is a critical factor when interpreting silver-stained colonic tissue in infants with pseudo-obstruction.