Related Experiment Video
Updated: Aug 13, 2026

Quantitative In vitro Assay to Measure Neutrophil Adhesion to Activated Primary Human Microvascular Endothelial Cells under Static Conditions
Published on: August 23, 2013
Autoantibodies to neutrophil granule proteins: pathogenic potential in vasculitis?
1Centre for Rheumatology/Bloomsbury Rheumatology Unit, Department of Medicine, University College London, England, UK.
Abstract:
The discovery of circulating autoantibodies to neutrophil granule proteins (ANCA), which are present in a high proportion of patients with vasculitis, has revitalised both clinical and experimental research in this area. Although their antigen specificities and strong association with vasculitic diseases have now been established, the role of ANCA in the disease process is uncertain. This review is a brief outline of some of the clinical associations of ANCA, and describes interesting new avenues being taken in recent research which may provide an insight into how ANCA may contribute to vascular damage in patients with vasculitis.
Related Concept Videos
Inflammation
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Antibody Actions
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
Determinants of Bacterial Pathogenicity and Virulence
Myasthenia Gravis ll: Pathophysiology
Gastritis II: Pathophysiology

