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Related Experiment Videos

Effect of low-density lateral interfaces on soft-tissue doses

M A Hunt1, G E Desobry, B Fowble

  • 1Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.

International Journal of Radiation Oncology, Biology, Physics
|January 15, 1997
PubMed
Summary

Radiation therapy can lead to underdosing in soft tissues next to lung inhomogeneities. The extent of this underdose depends on lung width, beam energy, and field size, potentially requiring adjustments in treatment planning for thoracic cancers.

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Radiotherapy Dosimetry

Background:

  • Dose distributions at perpendicular interfaces between tissues and low-density inhomogeneities are well-documented.
  • However, dose distributions at lateral interfaces, where the inhomogeneity is parallel to the beam direction, are less understood.
  • Lateral lung-soft-tissue interfaces are frequently encountered in thoracic radiotherapy for cancers like lung, esophageal, and breast cancer.

Purpose of the Study:

  • To evaluate the dose distribution along lateral lung-soft-tissue interfaces.
  • To determine the clinical implications of these dose distributions for cancer treatment.

Main Methods:

  • A phantom simulating lateral lung-soft-tissue interfaces was created using polystyrene and cork slabs.

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  • Irradiation was performed using a parallel plate ionization chamber to measure doses.
  • Dose distributions were analyzed by varying cork (lung) thickness, field size, beam energy (6-18 MV), and measurement depth.

    • Main Results:

    • Doses in the interface region were up to 10% lower than in homogeneous phantom conditions.
    • Underdosing increased with higher beam energies (e.g., 8% at 18 MV vs. 5% at 6 MV for 1-cm lung width).
    • Specific lateral distances from the interface were identified as necessary to ensure adequate dose coverage (e.g., 3-4 mm for 6 MV, 6-7 mm for 18 MV).

    Conclusions:

    • Underdosing is a significant concern in soft tissues adjacent to lateral lung interfaces in radiotherapy.
    • The magnitude of underdosing is influenced by lung width, beam energy, field size, and depth.
    • Treatment planning for thoracic and breast cancers may need to account for potential underdosing by adjusting beam energy or margins.