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Increased plasma cholesteryl ester transfer activity in obese children
H Hayashibe1, K Asayama, T Nakane
1Department of Pediatrics, Yamanashi Medical University, Nakakoma, Japan. hidemasa@res.yamanashi-med.ac.jp
Atherosclerosis
|February 28, 1997
Summary
Enhanced cholesteryl ester transfer protein (CETP) activity in obese children contributes to unhealthy lipoprotein profiles. This suggests CETP may play a role in the development of cardiovascular risk factors in this population.
Area of Science:
- Lipid Metabolism
- Pediatric Endocrinology
- Cardiovascular Disease Risk Factors
Background:
- Obesity in children is associated with dyslipidemia and an atherogenic lipoprotein profile.
- Cholesteryl ester transfer protein (CETP) facilitates the transfer of cholesteryl esters, influencing lipoprotein metabolism.
- The role of enhanced CETP activity in pediatric obesity-related dyslipidemia requires further investigation.
Purpose of the Study:
- To investigate the association between plasma CETP activity and atherogenic lipoprotein profiles in obese children.
- To determine if elevated CETP activity contributes to dyslipidemia in pediatric obesity.
Main Methods:
- Assayed plasma CETP activity using a micro-method involving exogenous lipoproteins.
- Analyzed serum lipid levels, apolipoproteins, and insulin in 31 obese children and compared them to nonobese controls.
Main Results:
- Obese children exhibited increased triglycerides, total cholesterol, LDL-C, and apo B levels, indicative of an atherogenic profile.
- Plasma CETP activity was significantly higher in obese children compared to controls.
- Elevated CETP activity correlated with atherogenic markers like LDL-C, TC:HDL-C, LDL-C:HDL-C, and apo B:apo Al ratios.
Conclusions:
- Increased plasma CETP activity is linked to atherogenic lipoprotein metabolism in obese children.
- Elevated CETP activity may be influenced by adiposity, insulin resistance, dyslipidemia, or lifestyle factors common in obese children.