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Functional magnetic resonance imaging in a stereotactic setup

J Debus¹, M Essig, L R Schad

¹Department of Radiology, German Cancer Research Center, Heidelberg, Germany.

Magnetic Resonance Imaging

|January 1, 1996

Summary

Functional MRI (fMRI) in a stereotactic setup accurately visualizes the motor and sensory cortex. This technique is crucial for precise pre-therapeutic assessment of brain function, enabling better treatment planning.

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Area of Science:

Neuroimaging
Medical Physics
Neurosurgery

Background:

Accurate localization of critical brain structures is essential for effective therapeutic strategy planning.
Functional MRI (fMRI) offers a method to assess the functional response of cortical structures to specific stimuli.

Purpose of the Study:

To present and evaluate two techniques for functional MRI (fMRI) within a stereotactic setup.
To demonstrate the feasibility of fMRI for pre-therapeutic assessment of cortical function.

Main Methods:

Utilized a stereotactic setup with either a ceramic frame or a precision mask for skull immobilization, ensuring no image distortion.
Employed a modified FLASH sequence on a 1.5 T MRI scanner with a specialized head coil, optimizing parameters for fMRI acquisition.

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Stimulated the motor cortex via sequential finger-to-thumb touching and analyzed signal changes using statistical parametric mapping (p < 0.001).

Main Results:

The primary motor and sensory cortex were successfully visualized in all 10 patients studied.
The implemented stereotactic fixation methods prevented motion artifacts, ensuring high-quality imaging.
fMRI in a stereotactic setup was demonstrated to be feasible using a standard 1.5 T MRI scanner.

Conclusions:

Functional MRI is a viable technique for precise pre-therapeutic assessment of cortical centers within a stereotactic framework.
This method provides crucial information for planning therapeutic interventions by accurately mapping brain function.