Related Experiment Video

Updated: Sep 18, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

[Treatment of chronic pulmonary aspergillosis (fungus ball type, mural thickness type)]

K Ogawa1

  • 1Department of Respiratory Disease, Higashi Nagoya National Hospital, Japan.

Kekkaku : [Tuberculosis]
|February 1, 1997
PubMed

Insights

Topical Amphotericin B shows promise for chronic pulmonary aspergillosis treatment. Concomitant Ulinastatin use may reduce bleeding symptoms like hemoptysis, with minimal side effects observed in this study.

Area of Science:

  • Pulmonology
  • Mycology
  • Infectious Diseases

Background:

  • Chronic pulmonary aspergillosis requires effective treatment strategies.
  • Tissue destruction from Aspergillus elastase is a concern.
  • Antifungal agents and elastase inhibitors are being explored.

Purpose of the Study:

  • To evaluate the clinical efficacy of topical Amphotericin B for chronic pulmonary aspergillosis.
  • To assess the impact of Ulinastatin, an elastase inhibitor, on hemosputum and hemoptysis in these patients.

Main Methods:

  • Topical Amphotericin B administered via transcatheter intracavity or transbronchial intrapulmonary injection, with optional inhalation.
  • Patients underwent an inhalation challenge test prior to topical treatment.
  • Ulinastatin administered intravenously alongside antifungal agents and hemostatics.

Main Results:

  • Topical Amphotericin B improved antifungal effects and clinical symptoms in 12 of 15 patients.
  • Ulinastatin treatment led to early resolution of hemosputum and hemoptysis in 11 of 23 episodes.
  • No treatment-related side effects requiring discontinuation were reported.

Conclusions:

  • Topical Amphotericin B is a desirable treatment for chronic pulmonary aspergillosis.
  • Concomitant Ulinastatin therapy is valuable for patients with severe bleeding symptoms.

More Related Videos

Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung15:01

Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung

Published on: September 18, 2021

Efficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways10:06

Efficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways

Published on: December 13, 2024

Related Concept Videos

Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...