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[Drug-induced laryngospasm]

T Nishikawa¹, K Munakata

¹Department of Internal Medicine, CONFORT Hospital, Yokohama.

Masui. the Japanese Journal of Anesthesiology

|February 1, 1997

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This case report details drug-induced laryngospasm from Chlorpromazine, a complication previously unreported. This finding suggests a potential cause for unexplained sudden deaths in patients on long-term Chlorpromazine therapy.

Area of Science:

Anesthesiology
Pharmacology
Emergency Medicine

Background:

Long-term Chlorpromazine therapy is associated with unexplained sudden deaths.
Anesthetic management requires careful consideration in patients with a history of long-term Chlorpromazine use.

Observation:

A 70-year-old male on 45-year Chlorpromazine therapy developed severe dyspnea and cyanosis after lidocaine administration.
Laryngospasm was diagnosed via vocal cord inspection during preparation for femur fracture surgery.

Findings:

This is the first reported case of drug-induced laryngospasm attributed to Chlorpromazine.
Immediate oral intubation successfully managed the laryngospasm without further complications.

Implications:

Related Experiment Videos

Chlorpromazine may induce laryngospasm, potentially explaining some unexplained sudden deaths in long-term users.
Anesthesiologists must be vigilant for Chlorpromazine-induced laryngospasm in at-risk patients.