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[Pathological spectrum of neuronal migration disorder]
1Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience.
No to Hattatsu = Brain and Development
|March 1, 1997
Summary
This review covers brain malformations from neuronal migration abnormalities, crucial for understanding intractable epilepsy. It details morphological changes in conditions like lissencephaly and focal cortical dysplasia.
Area of Science:
- Neuroscience
- Pathology
- Developmental Biology
Context:
- Intractable epilepsy is increasingly linked to specific brain malformations.
- Recent advancements highlight the surgical pathology of these conditions.
Purpose:
- To review a wide spectrum of brain pathologies occurring during the neuronal migration period.
- To describe morphological changes in various malformative lesions.
Summary:
- The article examines lesions resulting from abnormal neuronal migration.
- It details morphological changes in lissencephalies, polymicrogyria, microdysgenesis, and focal cortical dysplasia.
- Challenges in classifying these malformative brains are also discussed.
Impact:
- Enhances understanding of the neuropathology underlying intractable epilepsy.
- Provides a comprehensive overview for researchers and clinicians in neurosurgery and neurology.
- Contributes to improved diagnostic and classification frameworks for brain malformations.