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Infantile polymyositis with normal serum creatine kinase level
S Tütüncüoğlu1, H Tekgül, E Demirtaş
1Department of Pediatrics, Ege University Faculty of Medicine, Bornova-izmir, Turkey.
Insights
Infantile polymyositis can present with normal creatine kinase (CK) levels. Early steroid therapy, like oral prednisolone, led to complete recovery in a child with this condition, highlighting its effectiveness.
Area of Science:
- Pediatric Neurology
- Rheumatology
- Muscle Diseases
Background:
- A 30-month-old boy exhibited progressive proximal muscle weakness and atrophy starting at 11 months.
- Muscle biopsy revealed inflammatory infiltration, and EMG showed myopathic changes, suggesting polymyositis.
- Serum creatine kinase (CK) levels remained within normal ranges throughout the initial presentation.
Abstract:
A 30-month-old boy who has been suffering progressive proximal muscle weakness and severe atrophy in shoulder and hip muscles from 11 months of age had prominent perivascular inflammatory cellular infiltration in his muscle biopsy and myopathic EMG changes. But his serum creatine kinase (CK) levels were repeatedly found to be within normal ranges. Oral prednisolone therapy (2 mg/kg/d) brought a complete recovery of muscle power and normalization of EMG and muscle biopsy findings. This report provides an additional support that the cases of infantile polymyositis with normal serum CK levels may respond well to steroid therapy.