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Corneal chromoblastomycosis

K Barton1, D Miller, S C Pflugfelder

  • 1Corneal and External Disease Service, Bascom Palmer Eye Institute, University of Miami School of Medicine, Florida, USA.

Cornea
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

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Managing rare, pigmented mold corneal ulcers is challenging. Systemic itraconazole combined with surgery offers the best treatment outcome for corneal chromoblastomycosis caused by Fonsecaea pedrosoi.

Area of Science:

  • Ophthalmology
  • Mycology

Background:

  • Corneal ulceration caused by pigmented molds, such as Fonsecaea pedrosoi, presents a diagnostic and therapeutic challenge.
  • Fonsecaea pedrosoi is the most common cause of cutaneous chromoblastomycosis, a chronic fungal infection.

Observation:

  • A patient with recurrent corneal infection due to Fonsecaea pedrosoi initially responded to antifungal treatment but relapsed.
  • Intraocular fungal infection was confirmed through cultures from fibrinous membranes during multiple surgical interventions.

Findings:

  • Despite initial medical therapy and therapeutic penetrating keratoplasty, the corneal infection recurred.
  • Aggressive surgical management including large penetrating keratoplasty and cataract extraction, followed by a 5-month course of systemic itraconazole, led to disease resolution.

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Implications:

  • Corneal chromoblastomycosis caused by Fonsecaea pedrosoi is often resistant to standard medical therapy.
  • A combination of surgical intervention and systemic itraconazole appears to be the most effective treatment strategy for this challenging condition.