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Related Experiment Videos

Cognitive dysfunction in patients treated for pituitary tumours

K A Peace1, S M Orme, A R Thompson

  • 1Department of Psychological Medicine, Otago University, Dunedin, New Zealand.

Journal of Clinical and Experimental Neuropsychology
|February 1, 1997
PubMed
Summary

Patients treated for pituitary tumors show memory and executive function deficits, unrelated to mood or radiotherapy. These cognitive impairments are linked to pituitary surgery, suggesting multifactorial causes like neurosurgery or hormone imbalance.

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Psychology

Background:

  • Pituitary tumors can affect cognitive function.
  • Neuropsychological and mood assessments are crucial for understanding treatment sequelae.

Purpose of the Study:

  • To assess neuropsychological status and mood in patients treated for pituitary tumors.
  • To identify factors contributing to cognitive dysfunction post-treatment.

Main Methods:

  • Compared neuropsychological status and mood in 36 pituitary tumor patients and 36 healthy controls.
  • Excluded other known causes of cognitive dysfunction.
  • Analyzed relationships between cognitive deficits, mood, surgery, and radiotherapy.

Main Results:

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  • Patients exhibited significant impairments in memory and executive function compared to controls.
  • Cognitive deficits were related to the presence of surgery, not its type.
  • No differences in mood were observed between groups.
  • Deficits were not linked to mood disturbance or radiotherapy effects.

    • Conclusions:

    • Cognitive dysfunction, particularly in memory and executive function, persists after pituitary tumor treatment.
    • Surgery appears to be a significant factor, independent of surgical approach.
    • Multifactorial causes, including neurosurgery and potential hormone imbalances, are likely contributors to cognitive deficits.