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Haemostatic abnormalities in lung cancer: prognostic implications
G Buccheri1, D Ferrigno, C Ginardi
1Pulmonary Department, A. Carle Hospital, Cuneo, Italy.
European Journal of Cancer (Oxford, England : 1990)
|January 1, 1997
Summary
Coagulation disorders are common in cancer patients. This study found that a prethrombotic state, indicated by prolonged prothrombin time (PT) and increased D-dimer (DD), predicts a poor prognosis in lung cancer patients.
Area of Science:
- Oncology
- Hematology
- Medical Research
Background:
- Coagulation disorders are frequently observed in cancer patients, though clinical symptoms are rare.
- A prethrombotic state is implicated in the metastatic spread of cancer.
- Anticoagulant therapy has shown promise in specific lung cancer types.
Purpose of the Study:
- To investigate the prethrombotic state as a prognostic marker for lung cancer outcomes.
- To evaluate the association between specific coagulation factors and patient survival.
Main Methods:
- Prospective recording of pretreatment coagulation factors (PT, PTT, AT-III, P, F, DD) in 286 lung cancer patients.
- Collection of extensive clinical, laboratory, and pathological data.
- Long-term follow-up and survival analysis using Cox regression models.
Main Results:
- Prolonged PT, elevated fibrinogen (F), and increased D-dimer (DD) were significantly associated with a poor prognosis.
- Coagulation factors independently predicted survival, irrespective of other prognostic variables.
- Weak correlations were observed between most coagulation factors and other prognostic indicators.
Conclusions:
- A prethrombotic state, characterized by prolonged PT and elevated DD, is confirmed as an adverse prognostic factor in lung cancer.
- These findings support further research into anticoagulant therapies to manage hemostatic abnormalities in lung cancer.