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[Protected bacteriologic brushing in patients with severe copd]

R Zalacain1, V Achótegui, I Pascal

  • 1Servicio de Neumología, Hospital de Cruces, Vizcaya.

Archivos De Bronconeumologia
|January 1, 1997
PubMed
Summary

Severe chronic obstructive pulmonary disease (COPD) patients often have significant germ concentrations, even in stable phases. Bacteriological findings may not align with clinical status, indicating a need for further investigation in COPD management.

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Area of Science:

  • Pulmonary Medicine
  • Microbiology
  • Respiratory Diseases

Background:

  • Severe chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation.
  • Bacterial infections are common in COPD exacerbations, but their presence in stable phases is less understood.
  • Understanding germ presence is crucial for managing COPD patients.

Purpose of the Study:

  • To determine the presence and concentration of germs in severe COPD patients.
  • To compare germ findings between stable and acute phases of COPD.
  • To assess the relationship between clinical status and bacteriological findings.

Main Methods:

  • Twenty-six severe COPD patients (14 stable, 12 acute phase) were enrolled without recent antibiotic or corticoid treatment.

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  • Bronchial-Protected Specimen (BPS) sampling was performed using aerosol anesthesia.
  • A positive finding was defined as > or = 10(3) CFU/ml; H. influenzae was the most common microorganism detected.

    • Main Results:

    • 57.1% of stable COPD patients and 66.7% of acute-phase patients showed positive BPS findings (p = NS).
    • H. influenzae was the most frequently identified microorganism in both groups.
    • Mean germ concentrations were 8,625 CFU/ml in stable and 17,375 CFU/ml in acute-phase patients (p = NS).

    Conclusions:

    • A significant proportion of stable severe COPD patients harbor substantial germ concentrations.
    • Germ concentrations were not significantly higher in acute-phase patients compared to stable patients.
    • Clinical status and bacteriological findings in severe COPD may not always correlate.