[Antioxidant system disorder in diabetic patients and the means for its normalization]

The condition was studied on the antioxidant system (AOS)--the activities of catalase, concentration of tocoferoli and reduced glutathione--in 112 patients with type I diabetes mellitus during the course of treatment. It has been established that in decompensation of diabetes mellitus there is a striking deterioration of AOS the degree of which depends upon duration and severity of the illness as well as the presence of angiopathies. Employment in the combined treatment of the donator of sulphhydric groups unithiol and a naturally occurring antioxidant tocopheroli promoted normalization of parameters associated with AOS, diabetic angiopathies included.