Magnesium, calcium and trace elements in spontaneously hypertensive rats

Area of Science:

• Biochemistry
• Gerontology
• Cardiovascular Research

Background:

• Vascular complications are a concern in aging and hypertension.
• Electrolytes and trace elements play crucial roles in cellular function and tissue integrity.

Purpose of the Study:

• To investigate the relationship between electrolytes/trace elements and vascular complications in aging.
• To compare element levels in hypertensive (SHRSP, SHRSR) and normotensive (WKY) rat strains across different ages.

Main Methods:

• Analysis of ash materials and cellular supernatant fractions from various rat tissues.
• Measurement of selenium, magnesium, calcium, and alpha-tocopherol concentrations.
• Comparison between adult and old female rats, and between hypertensive and normotensive strains.

Main Results:

• A decrease in tissue selenium was observed in old female SHRSP and WKY rats compared to adults.
• SHRSP rats exhibited decreased magnesium and an elevated calcium-to-magnesium ratio in multiple tissues.
• Diabetic rat models showed decreased myocardial magnesium and an increased myocardial calcium-to-magnesium ratio.
• Lower alpha-tocopherol concentrations were found in the myocardium and cerebrum of old female SHRSR rats.

Conclusions:

• An elevated calcium-to-magnesium ratio in aged rats and SHRSP indicates a tendency towards tissue deterioration.
• Decreased tissue selenium in aged rats and SHRSP may be linked to peroxidation and tissue damage.
• These findings highlight the critical role of specific electrolytes and trace elements in aging-related vascular health.