[Pregnancy complicated with symptomatic polyhydramnios: treatment with indomethacin]

This is a prospective and experimental trial with the objective of treating pregnancies complicated with symptomatic polyhydramnios. Patients with pregnancies between 24 and 25 weeks, index of amniotic fluid greater than 24 and with symptoms associated to polyhydramnios such as abdominal discomfort, respiratory distress and premature uterine contractions, were entered into the trial. The medication utilized was Indomethacin 25 mg p.o. every six hours until symptoms disappear and the index of amniotic fluid was less than 24. Eight patients were treated during an eight months period. The average age was 30 years, with a rank between 25 and 37 years. There were only two nulliparous and the average gestational age was 30 weeks. The patients were classified in this way: three with idiopathic polyhydramnios, two with twin pregnancies, one with diabetes mellitus and two pregnancies, one with diabetes mellitus and two pregnancies with fetal malformations. 18 trisomy was diagnosed in the newborn from one of the patients with idiopathic polyhydramnios. The average index of amniotic fluid upon initiating the treatment was of 33.6 and 18 upon finishing. The maximum treatment time was six days with average four. Ultrasonographic control was obtained every 24 hours and fetal echocardiogram at 24 and 96 hours of treatment. There were no maternal nor fetal side effects. Success rate correcting symptomatic polyhydramnios with Indomethacin was 100%.