Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Posterior urethral valves: long-term renal function consequences after transplantation

L Salomon1, E Fontaine, M F Gagnadoux

  • 1Department of Urology, Ambroise Paré Hospital, University of West Paris, Boulogne, France.

The Journal of Urology
|March 1, 1997
PubMed
Summary

Renal transplantation is effective for children with posterior urethral valves, showing similar graft survival to controls. Long-term graft function decline may relate to lower urinary tract issues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estimation of carbon footprint in nuclear medicine: illustration of a french department.

European journal of nuclear medicine and molecular imaging·2025
Same author

Administration of neoadjuvant chemotherapy for muscle-invasive bladder cancer in real life: Are urologists still too cautious?

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2021
Same author

[Enteral nutrition in malnourished patients with lung cancer].

Revue des maladies respiratoires·2020
Same author

Sexual dysfunction after elective laparoscopic or endovascular abdominal aortic aneurysm repair in men.

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2020
Same author

Secondary bladder exstrophy repair with a bilateral gracilis muscle flap in an adult female patient: Case report of an original procedure.

Annales de chirurgie plastique et esthetique·2018
Same author

[Comparison of operative and oncologic results between partial nephrectomy and radiofrequency ablation for treatment of renal tumors in patients older than 75].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2017

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Transplantation Immunology

Background:

  • Posterior urethral valves (PUV) are a common cause of congenital lower urinary tract obstruction in male infants.
  • Kidney transplantation is a life-saving option for children with end-stage renal disease due to PUV.
  • Long-term outcomes of renal transplantation in children with PUV require further evaluation.

Purpose of the Study:

  • To assess the long-term efficacy and graft survival of renal transplantation in pediatric patients with posterior urethral valves.
  • To compare outcomes between children with PUV and a control group with other malformation uropathies.

Main Methods:

  • Retrospective cohort study comparing 66 children with PUV to 116 control patients.
  • Analysis of graft survival rates at 5 and 10 years post-transplantation.

Related Experiment Videos

  • Evaluation of serum creatinine levels as an indicator of long-term graft function.

    • Main Results:

    • Graft survival rates at 5 years were 69% for PUV and 72% for controls; at 10 years, 54% for PUV and 50% for controls (not statistically significant).
    • A statistically significant increase in serum creatinine was observed at 10 years in the PUV group, indicating graft function deterioration.
    • No significant increase in serum creatinine was noted in the control group.

    Conclusions:

    • Renal transplantation in children with posterior urethral valves demonstrates comparable long-term graft survival to other uropathies.
    • Deterioration of graft function over time in PUV patients is likely associated with underlying lower urinary tract dysfunction.
    • Further management strategies should consider the impact of lower urinary tract issues on transplanted kidney function.