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Abstract:
Cancer is an acquired disease in which it is possible to identify a variety of abnormalities at a genetic level. This holds a promise that genetic manipulation of tumour cells will lead to novel therapies. As yet these approaches are constrained by available methods for obtaining gene transfer and subsequent genetic control. However, a number of strategies are already reaching the clinic, including attempts at immunotherapy, prodrug activation and improving host defence against conventional chemotherapy. Further clinical opportunities will occur with improved vector development.
Insights
Genetic manipulation of cancer cells shows promise for novel therapies. Current gene transfer methods are limited, but clinical strategies like immunotherapy and prodrug activation are advancing, with vector development key for future treatments.
Area of Science:
- Oncology
- Cancer Genetics
- Gene Therapy
Background:
- Cancer is characterized by genetic abnormalities.
- Genetic manipulation of tumor cells offers potential for new therapeutic strategies.
- Current gene transfer and control methods present limitations.