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Related Experiment Videos

Molecular tumour clocks

D Shibata

    Annals of Medicine
    |February 1, 1997
    PubMed
    Summary
    This summary is machine-generated.

    Cancer progression is hard to study in humans. Microsatellite mutations in tumors act as molecular clocks, with differences in their numbers potentially indicating relative cancer ages.

    Area of Science:

    • Oncology
    • Genetics
    • Evolutionary Biology

    Background:

    • Multistep tumor progression involves sequential mutations and cell divisions.

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  • Directly observing human cancer evolution over time is challenging.
  • Phylogenetic methods can reconstruct the history of cancer mutations and clonal expansions.