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Methicillin hemorrhagic cystitis
Antimicrobial Agents and Chemotherapy
|September 1, 1977
Summary
Methicillin can cause hemorrhagic cystitis, a bladder inflammation. This study identified six cases of this side effect in patients undergoing methicillin treatment.
Area of Science:
- Nephrology
- Urology
- Pharmacology
Background:
- Interstitial nephritis is a known adverse effect of methicillin.
- Hemorrhagic cystitis is an underreported complication associated with methicillin therapy.
Purpose of the Study:
- To investigate the occurrence and clinical presentation of hemorrhagic cystitis in patients treated with methicillin.
Main Methods:
- Case series review of patients receiving methicillin.
- Clinical evaluation including cystoscopy for diagnosis confirmation.
Main Results:
- Six patients exhibited evidence of hemorrhagic cystitis during methicillin therapy.
- Cystoscopic examination confirmed the diagnosis in three of the affected patients.
Conclusions:
- Hemorrhagic cystitis should be considered as a potential complication of methicillin treatment.
- Further investigation is warranted to understand the mechanism and incidence of methicillin-induced hemorrhagic cystitis.