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Methicillin hemorrhagic cystitis

R Bracis, C V Sanders, D N Gilbert

    Antimicrobial Agents and Chemotherapy
    |September 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Methicillin can cause hemorrhagic cystitis, a bladder inflammation. This study identified six cases of this side effect in patients undergoing methicillin treatment.

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    Area of Science:

    • Nephrology
    • Urology
    • Pharmacology

    Background:

    • Interstitial nephritis is a known adverse effect of methicillin.
    • Hemorrhagic cystitis is an underreported complication associated with methicillin therapy.

    Purpose of the Study:

    • To investigate the occurrence and clinical presentation of hemorrhagic cystitis in patients treated with methicillin.

    Main Methods:

    • Case series review of patients receiving methicillin.
    • Clinical evaluation including cystoscopy for diagnosis confirmation.

    Main Results:

    • Six patients exhibited evidence of hemorrhagic cystitis during methicillin therapy.
    • Cystoscopic examination confirmed the diagnosis in three of the affected patients.

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    Conclusions:

    • Hemorrhagic cystitis should be considered as a potential complication of methicillin treatment.
    • Further investigation is warranted to understand the mechanism and incidence of methicillin-induced hemorrhagic cystitis.