Ectopic Pregnancy Treated by Combined Laparoscopic Surgery and Methotrexate

Area of Science:

• Reproductive Medicine
• Minimally Invasive Surgery
• Gynecologic Oncology

Background:

• Ectopic pregnancy poses significant risks to maternal health.
• Current management options for ectopic pregnancy include medical and surgical interventions.
• There is a need for minimally invasive and effective treatment strategies.

Purpose of the Study:

• To evaluate the efficacy and safety of a conservative laparoscopic surgical approach combined with methotrexate injection for treating ectopic pregnancy.
• To assess the impact of this combined treatment on human chorionic gonadotropin levels.
• To determine the reproductive outcomes following this management protocol.

Main Methods:

• Seven women diagnosed with ectopic pregnancy underwent conservative laparoscopic surgery.
• Methotrexate (50 mg) was injected into the proximal segment of the involved fallopian tube.
• Beta-subunit human chorionic gonadotropin levels were monitored at 7, 14, and 30 days post-procedure.

Main Results:

• The combined approach was successfully performed in all seven patients.
• Significant decreases in beta-subunit human chorionic gonadotropin levels were observed.
• No intraoperative or postoperative surgical complications or methotrexate side effects were reported.
• Five out of seven women achieved subsequent pregnancies with no miscarriages or recurrent ectopic pregnancies.

Conclusions:

• Conservative laparoscopic surgery with methotrexate injection is a viable and safe alternative for managing ectopic pregnancy.
• This minimally invasive technique offers favorable outcomes, including successful future pregnancies.
• The combined approach presents a practical alternative to existing ectopic pregnancy management protocols.