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Related Experiment Videos

Mortality from Parkinson disease

E D Louis1, K Marder, L Cote

  • 1Department of Neurology, Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.

Archives of Neurology
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

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Parkinson disease (PD) patients face a 2-5 fold increased mortality risk, significantly influenced by dementia and severe extrapyramidal signs (EPSs), particularly bradykinesia.

Area of Science:

  • Neurology
  • Geriatrics
  • Epidemiology

Background:

  • Levodopa therapy improves quality of life in Parkinson disease (PD) but high mortality persists.
  • The impact of dementia and extrapyramidal signs (EPSs) on PD mortality remains unclear.

Purpose of the Study:

  • To investigate the influence of dementia and EPS severity on mortality risk in PD patients.

Main Methods:

  • Comparative study of PD patients and elderly controls (demented and nondemented).
  • Annual neurological and neuropsychological examinations.
  • Dementia diagnosis via DSM-III-R criteria; EPS rating using the Unified Parkinson's Disease Rating Scale.
  • Survival analysis using Kaplan-Meier and Cox proportional hazards models.

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Main Results:

  • PD patients with dementia had the highest mortality risk (rate ratio, 4.9).
  • PD patients without dementia also showed elevated mortality risk (rate ratio, 2.7).
  • Dementia alone increased mortality risk (rate ratio, 1.6); severe baseline EPS, especially bradykinesia, predicted earlier mortality.

Conclusions:

  • PD patients face a 2-5 fold increased mortality risk compared to nondemented individuals.
  • Severe EPS, particularly bradykinesia, and dementia are significant contributors to increased mortality in PD.
  • Despite treatment advances, these factors substantially elevate mortality in Parkinson disease.