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Cholecystokinin cells

R A Liddle1

  • 1Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.

Annual Review of Physiology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Cholecystokinin (CCK) regulates digestion by stimulating pancreatic secretion and gallbladder contraction. This review explores how ingested nutrients control CCK cell secretion via intracellular pathways and releasing factors.

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Area of Science:

  • Gastroenterology and endocrinology
  • Neuroscience and neuroendocrinology

Background:

  • Cholecystokinin (CCK) is a key hormonal regulator of digestion, secreted by intestinal endocrine cells and neurons.
  • CCK influences pancreatic secretion, gallbladder contraction, gastric emptying, and satiety, coordinating nutrient ingestion, digestion, and absorption.
  • CCK acts as both a hormone in the gut and a neuropeptide in the nervous system.

Purpose of the Study:

  • This review focuses on the intestinal CCK cell's physiology.
  • It specifically examines the regulation of CCK hormone secretion.
  • The review details how ingested nutrients and intracellular signaling control CCK release.

Main Methods:

  • Review of existing literature on CCK cell physiology.
  • Analysis of studies on nutrient effects on CCK secretion.

Related Experiment Videos

  • Summary of research on CCK cell electrophysiology and releasing factors.

    • Main Results:

    • Ingested nutrients modulate CCK cell secretion through specific intracellular messenger systems.
    • Electrophysiological studies reveal insights into CCK cell activity.
    • Newly identified proteins act as CCK releasing factors, mediating feedback regulation.

    Conclusions:

    • CCK secretion is tightly regulated by ingested nutrients and intracellular signaling pathways.
    • Understanding CCK cell physiology is crucial for comprehending digestive regulation.
    • New releasing factors highlight critical feedback mechanisms in CCK secretion.