Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Osmoreceptors in the central nervous system

C W Bourque1, S H Oliet

  • 1Centre for Research in Neuroscience, Montreal General Hospital, Canada.

Annual Review of Physiology
|January 1, 1997
PubMed
Summary

Osmoreceptors control body fluid balance by regulating sodium and water. In rats, specific ion channels in magnocellular neurosecretory cells detect osmotic changes, influencing oxytocin and vasopressin release for osmoregulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clock-driven vasopressin neurotransmission mediates anticipatory thirst prior to sleep.

Nature·2016
Same author

Effects of Salt Loading on the Regulation of Rat Hypothalamic Magnocellular Neurosecretory Cells by Ionotropic GABA and Glycine Receptors.

Journal of neuroendocrinology·2016
Same author

Effects of Salt Loading on the Morphology of Astrocytes in the Ventral Glia Limitans of the Rat Supraoptic Nucleus.

Journal of neuroendocrinology·2016
Same author

Mechanical basis of osmosensory transduction in magnocellular neurosecretory neurones of the rat supraoptic nucleus.

Journal of neuroendocrinology·2015
Same author

Circadian modulation of osmoregulated firing in rat supraoptic nucleus neurones.

Journal of neuroendocrinology·2012
Same author

Functional N-Methyl-D-Aspartate and Non-N-Methyl-D-Aspartate Receptors are Expressed by Rat Supraoptic Neurosecretory Cells in vitro.

Journal of neuroendocrinology·2009

Area of Science:

  • Neuroscience
  • Physiology
  • Endocrinology

Background:

  • Osmoreceptors maintain extracellular fluid (ECF) osmotic pressure homeostasis.
  • Magnocellular neurosecretory cells (MNCs) control oxytocin and vasopressin release, crucial for osmoregulation via natriuresis and diuresis.
  • Osmosensitive neurons in the organum vasculosum lamina terminalis (OVLT) modulate MNC firing rates.

Purpose of the Study:

  • To characterize the cellular mechanisms underlying osmoreceptor potentials in MNCs.
  • To elucidate how osmotic stimuli are transduced into electrical signals in MNCs.

Main Methods:

  • Patch-clamp recordings from isolated MNCs from the rat supraoptic nucleus.
  • Morphometric analysis of MNCs.
  • Review of experimental details within a physiological context.

Main Results:

  • Osmotically evoked changes in MNC cell volume are transduced into membrane potential changes.
  • Stretch-inactivated cationic channels in MNCs are responsible for this transduction process.

Conclusions:

  • The study details the cellular basis of osmoreception in MNCs.
  • Stretch-inactivated cationic channels are key players in translating osmotic shifts into neurosecretory responses.

Related Experiment Videos