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Decrease in serum levels of thyroid hormone in patients with coronary heart disease

S Miura1, M Iitaka, S Suzuki

  • 1Fourth Department of Internal Medicine, Saitama Medical School, Japan.

Endocrine Journal
|December 1, 1996
PubMed
Summary
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This study found that coronary heart disease (CHD) patients have reduced thyroid function and lower HDL cholesterol. However, subclinical hypothyroidism and thyroid autoimmunity were not directly linked to CHD development in this cohort.

Area of Science:

  • Cardiology
  • Endocrinology
  • Thyroidology

Background:

  • Coronary heart disease (CHD) is a leading cause of mortality worldwide.
  • Thyroid dysfunction, including subclinical hypothyroidism and autoimmune thyroid disease, is increasingly recognized for its potential systemic effects.
  • The relationship between thyroid function and CHD remains an area of active investigation.

Purpose of the Study:

  • To investigate the association between subclinical hypothyroidism and/or autoimmune thyroid disease and the presence of coronary heart disease (CHD).
  • To compare thyroid function, thyroid autoantibodies, and serum lipid profiles in patients with CHD versus healthy controls.

Main Methods:

  • A case-control study involving 97 patients with CHD (diagnosed via coronary angiography) and 103 healthy controls.

Related Experiment Videos

  • Measurements included thyroid function tests (TSH, FT3, FT4), thyroid autoantibodies, and serum lipid concentrations (including HDL-C).
  • Statistical analyses were performed to compare parameters between groups, with subgroup analyses for gender and exclusion of comorbidities like diabetes mellitus (DM) and hypertension (HT).

    • Main Results:

    • Patients with CHD demonstrated significantly lower serum free T3 (FT3) and free T4 (FT4) levels, and higher TSH levels, indicating reduced thyroid function compared to controls.
    • Serum high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in the CHD group, irrespective of gender.
    • The prevalence of subclinical hypothyroidism and thyroid autoantibodies was similar between CHD patients and controls. No difference in serum lipid levels was observed between CHD patients with subclinical hypothyroidism and those with normal thyroid function.

    Conclusions:

    • While CHD patients exhibit impaired thyroid function and lower HDL-C levels, subclinical hypothyroidism and thyroid autoimmunity do not appear to be directly associated with the development of CHD in this study population.
    • Lower thyroid hormone levels and reduced HDL-C are significant findings in CHD patients, warranting further investigation.
    • The study suggests that gender-specific factors may influence the interplay between thyroid function, lipids, and CHD.