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Cimetidine in bleeding peptic ulcer

A M Hoare, G V Bradby, C F Hawkins

    Lancet (London, England)
    |September 29, 1979
    PubMed
    Summary
    This summary is machine-generated.

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    Cimetidine may prevent further gastric ulcer bleeding but not duodenal ulcer bleeding after acute gastrointestinal hemorrhage. This randomized trial investigated cimetidine

    Area of Science:

    • Gastroenterology
    • Clinical Pharmacology

    Background:

    • Acute gastrointestinal hemorrhage from peptic ulcers poses a significant risk of re-bleeding.
    • Peptic ulcers, including gastric and duodenal types, are common causes of upper GI bleeding.

    Purpose of the Study:

    • To investigate the efficacy of cimetidine in reducing the risk of further bleeding shortly after acute gastrointestinal hemorrhage from peptic ulcers.
    • To determine if cimetidine's effect differs between gastric and duodenal ulcers.

    Main Methods:

    • A double-blind, randomized controlled trial was conducted.
    • 34 patients received cimetidine, and 32 received a placebo.
    • Patients were matched for age, sex, and severity of hemorrhage.

    Main Results:

    Related Experiment Videos

    • Overall, 8 patients on cimetidine and 15 on placebo experienced further bleeding within a week.
    • Cimetidine showed no significant effect on re-bleeding rates for duodenal ulcers.
    • For gastric ulcers, only 2 of 14 patients on cimetidine re-bled, compared to 10 of 19 on placebo.

    Conclusions:

    • Cimetidine may be beneficial in preventing recurrent hemorrhage specifically from gastric ulcers.
    • Cimetidine does not appear to reduce the risk of further bleeding from duodenal ulcers.
    • Further research may be warranted to explore the specific mechanisms behind cimetidine's differential effect on gastric vs. duodenal ulcer bleeding.