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Myocardial Infarction and Functional Outcome Assessment in Pigs
Published on: April 25, 2014
The relationship between the electrocardiographic pattern with TIMI flow class and ejection fraction in patients with
J Kusniec1, A Solodky, B Strasberg
1Department of Cardiology, Rabin Medical Center, Petah Tiqva, Israel.
Insights
Electrocardiogram findings of an isoelectric ST segment and negative T wave predict a patent left anterior descending artery after acute anterior myocardial infarction. This ECG pattern also correlates with improved left ventricular function.
Area of Science:
- Cardiology
- Diagnostic Imaging
- Internal Medicine
Background:
- Acute anterior wall myocardial infarction (MI) is a critical cardiovascular event.
- Assessing left anterior descending (LAD) artery patency and left ventricular ejection fraction (LVEF) is crucial for patient outcomes.
- Electrocardiogram (ECG) is a readily available diagnostic tool.
Purpose of the Study:
- To evaluate the predictive value of ECG findings for LAD artery patency.
- To assess the correlation between specific ECG patterns and LVEF in patients post-anterior MI.
- To determine the utility of discharge ECG in predicting coronary artery status.
Main Methods:
- 116 patients with first acute anterior MI were studied.
- Coronary angiography and left ventriculography were performed before discharge.
- ECG parameters (ST segment, T wave in V2-V4) were analyzed and compared with TIMI flow and LVEF.
Main Results:
- Isoelectric ST segments and negative T waves on ECG were associated with a higher incidence of TIMI flow 3 (patent LAD artery).
- Patients with ST segment elevation and positive T waves showed significantly lower rates of TIMI flow 3.
- Isoelectric ST segments correlated with a better left ventricular ejection fraction (57.8% vs 41.7%).
Conclusions:
- ECG patterns of isoelectric ST segment and negative T wave are valuable predictors of LAD artery patency in acute anterior MI.
- These ECG findings also indicate preserved left ventricular function.
- Discharge ECG can provide prognostic information regarding coronary artery patency and cardiac function.
Aims:
The aim of this study was to assess the value of the electrocardiogram in predicting the patency of the left anterior descending artery and left ventricular ejection fraction in patients with a first acute anterior wall myocardial infarction at discharge from the coronary care unit.
Method:
We included 116 consecutive patients with an acute anterior myocardial infarction who had undergone coronary angiography and left ventriculography before discharge from the coronary care unit (7th to 10th day). The ST segment, either elevated or isoelectric (< 1 mm), and the T wave (positive or negative) in precordial leads V2-V4 were analysed and compared to the TIMI flow from each patient.
Results:
Out of 69 patients with negative T waves, 38 (55%) had TIMI flow 3 compared with 20 (29%) and 11 (16%) with TIMI flow 2 and 0-1, respectively; and out of 47 patients with positive T waves seven (15%) had TIMI flow 3, 17 (36%) TIMI flow 2 and 23 (49%) TIMI flow 0-1 (P < 0.001). Out of 63 patients with an isoelectric ST segment, 35 (55%) had TIMI flow 3, 18 (29%) TIMI flow 2 and 10 (16%) TIMI flow 0-1, and out of 53 with ST segment elevation, 10 (19%) had TIMI flow 3, 19 (36%) TIMI flow 2 and 24 (45%) TIMI flow 0-1 (P < 0.001). When both parameters were analysed together, we found that in 46 patients with both isoelectric ST segments and negative T waves, 30 (65%) had TIMI flow 3 compared with two of 30 (7%) patients with ST segment elevation and positive T waves (P < 0.001). Patients with isoelectric ST segments had a better degree of left ventricular ejection fraction (57.8 +/- 14.1%) than patients with ST segment elevation (41.7 +/- 13%) (P < 0.001). Patients with positive and negative T waves had a similar left ventricular ejection fraction (49 +/- 18.1% vs 51 +/- 14%).
Conclusion:
We concluded that patients with a first acute anterior myocardial infarction and an electrocardiogram pattern of an isoelectric ST segment and a negative T wave have a higher incidence of a patent left anterior descending coronary artery than similar patients with ST segment elevation and a positive T wave. An isoelectric ST segment is also related to better left ventricular function.
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