Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A one-dimensional representation of protein structure

T W Barlow1, W G Richards

  • 1Physical and Theoretical Chemistry Laboratory, Oxford University, U.K.

Journal of Molecular Graphics
|August 1, 1996
PubMed
Summary

This study presents a novel one-dimensional method for describing protein tertiary structure using angles between C alpha-C alpha links. This approach achieves high accuracy, approximately 3 Angstroms, for structural representation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sclerostin and DKK1 Inhibition Preserves and Augments Alveolar Bone Volume and Architecture in Rats with Alveolar Bone Loss.

Journal of dental research·2018
Same author

Fibroblast growth factor 23 (FGF23) and alpha-klotho stimulate osteoblastic MC3T3.E1 cell proliferation and inhibit mineralization.

Calcified tissue international·2011
Same author

Syphilis and the Wassermann reaction.

The Urologic and cutaneous review·2010
Same author

Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients.

British journal of cancer·2008
Same author

A microaliquoting technique for precise histological annotation and optimization of cell content in frozen tissue specimens.

Biotechnic & histochemistry : official publication of the Biological Stain Commission·2007
Same author

CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight.

Regulatory peptides·2005

Area of Science:

  • Biophysics
  • Structural Biology
  • Computational Biology

Background:

  • Understanding protein tertiary structure is crucial for deciphering biological function.
  • Accurate and efficient methods for protein structure representation are essential for bioinformatics and drug discovery.

Purpose of the Study:

  • To develop a simplified one-dimensional representation of protein tertiary structure.
  • To evaluate the accuracy of this new representation in describing protein structural details.

Main Methods:

  • A one-dimensional representation was derived from a two-dimensional depiction of protein structure.
  • The representation utilizes angles between consecutive C alpha-C alpha links.

Main Results:

  • The one-dimensional representation accurately describes protein tertiary structure.
  • The method achieves an accuracy of approximately 3 Angstroms.

Conclusions:

  • This simplified one-dimensional method offers an efficient way to represent protein tertiary structure.
  • The high accuracy of this approach has implications for structural biology and computational analyses.

Related Experiment Videos