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A new irreversibly inhibited form of xanthine oxidase from ethylisonitrile
S A Holmer1, C L Houlton, T D Westmoreland
1Department of Chemistry, Wesleyan University, Middletown, CT 06459-0180, USA.
Journal of Inorganic Biochemistry
|April 1, 1997
Abstract:
The treatment of xanthine oxidase with ethylisonitrile results in irreversible inhibition of the catalytic activity. Chemical and spectroscopic evidence suggests that the inhibited enzyme is a new distinct derivative in which the essential sulfido ligand to molybdenum has been modified or removed.